Independence between GTPase active sites in the Escherichia coli cell division protein FtsZ.

Abstract

We have analyzed the substrate kinetics of the GTPase activity of FtsZ and the effects of two different GTPase inhibitors, GDP and the slowly hydrolyzable GTP analogue GMPCPP. In the absence of inhibitors the GTPase activity follows simple Michaelis-Menten kinetics, and both GDP and GMPCPP inhibited the activity in a competitive manner. These results… (More)
DOI: 10.1016/j.febslet.2011.10.046

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