Indenolol: A New Antihypertensive Agent: Efficacy, Toxicity, and Hemodynamic Effects in a Crossover Double‐Blind Study With Metoprolol

@article{Trimarco1985IndenololAN,
  title={Indenolol: A New Antihypertensive Agent: Efficacy, Toxicity, and Hemodynamic Effects in a Crossover Double‐Blind Study With Metoprolol},
  author={Bruno Trimarco and Alberto Cuocolo and Gisela Groothold and Bruno Ricciardelli and Nicola De Luca and Massimo Volpe and A. M. Veniero and Mario Condorelli},
  journal={The Journal of Clinical Pharmacology},
  year={1985},
  volume={25}
}
The antihypertensive efficacy of a new agent, indenolol, was compared with that of the well‐established antihypertensive drug, metoprolol, and its hemodynamic effects were investigated using echocardiography. Eighteen hypertensives completed a double‐blind, crossover, randomized study using indenolol and metoprolol. Two four‐week courses with indenolol or metoprolol were preceded and followed by a two‐week placebo period; the total duration of the study was 14 weeks. Indenolol proved to be… 
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6 Citations

6 Citations

Renal and Limb Vasodilatation during Acute Beta‐Adrenoceptor Blockade with Indenolol
Indenolol is a noncardioselective beta‐adrenoceptor blocking drug with partial agonist activity. The mechanism of its acute antihypertensive activity has been evaluated in a double‐blind, inpatient,…
Indenolol, a β‐blocker with partial agonism at vascular β‐adrenoceptors
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Indenolol vasodilated forearm arterioles and this effect was antagonized by β‐blockade, thus demonstrating vascular intrinsic sympathomimetic activity, which may contribute to its therapeutic action in human beings.
Meta-Analysis of the Hemodynamic Properties of Antihypertensive Medications
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A meta-analysis of studies involving the treatment of hypertension using the effect of ACEIs, β-blockers, CCBs and thiazide diuretics on plasma volume, cardiac output or stroke volume found that the various classes of antihypertensive medications differ from each other in terms of their non-blood pressure lowering hemodynamic properties.
Acute effect of indenolol on human airways
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The mechanism of action of indenolol is discussed in the light of the lack of its acute effect on airways resistance, and the non-cardioselective agent (propranolol) was more effective than the cardioseLECTive compound (atenolol) in decreasing the expiratory flow.
Overview: Cardiovascular Therapy Involving β-Adrenoceptor Partial Agonists
Effects of indenolol on blood pressure, lower limb blood flow, adrenergic reflexes, and plasma renin activity
TLDR
Indenolol possesses an antihypertensive activity associated with reduction of vascular resistance and lower limb vascular resistance was significantly lowered, thus suggesting an intrinsic sympathomimetic activity.

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