Indenolol: A New Antihypertensive Agent: Efficacy, Toxicity, and Hemodynamic Effects in a Crossover Double‐Blind Study With Metoprolol

@article{Trimarco1985IndenololAN,
  title={Indenolol: A New Antihypertensive Agent: Efficacy, Toxicity, and Hemodynamic Effects in a Crossover Double‐Blind Study With Metoprolol},
  author={Bruno Trimarco and Alberto Cuocolo and Gisela Groothold and Bruno Ricciardelli and Nicola De Luca and Massimo Volpe and A. M. Veniero and Mario Condorelli},
  journal={The Journal of Clinical Pharmacology},
  year={1985},
  volume={25}
}
The antihypertensive efficacy of a new agent, indenolol, was compared with that of the well‐established antihypertensive drug, metoprolol, and its hemodynamic effects were investigated using echocardiography. Eighteen hypertensives completed a double‐blind, crossover, randomized study using indenolol and metoprolol. Two four‐week courses with indenolol or metoprolol were preceded and followed by a two‐week placebo period; the total duration of the study was 14 weeks. Indenolol proved to be… 
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Effects of indenolol on blood pressure, lower limb blood flow, adrenergic reflexes, and plasma renin activity
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