Indene-based scaffolds. Design and synthesis of novel serotonin 5-HT6 receptor ligands.

@article{Alcalde2008IndenebasedSD,
  title={Indene-based scaffolds. Design and synthesis of novel serotonin 5-HT6 receptor ligands.},
  author={Ermitas Alcalde and Neus Mesquida and Jordi Frigola and Sara L{\'o}pez-P{\'e}rez and Ramon Merc{\'e}},
  journal={Organic & biomolecular chemistry},
  year={2008},
  volume={6 20},
  pages={3795-810}
}
A series of novel indene derivatives designed by a scaffold selection gave access to several examples of (Z)-arylmethylideneindenes and indenylsulfonamides that acted as serotonin 5-HT(6) receptor ligands. Different synthetic multistep routes could be applied to these target compounds, each with their own complexity and limitations. A reasonable route… CONTINUE READING