Indanylidenes. 1. Design and synthesis of (E)-2-(4,6-difluoro-1-indanylidene)acetamide, a potent, centrally acting muscle relaxant with antiinflammatory and analgesic activity.

@article{Musso2003Indanylidenes1D,
  title={Indanylidenes. 1. Design and synthesis of (E)-2-(4,6-difluoro-1-indanylidene)acetamide, a potent, centrally acting muscle relaxant with antiinflammatory and analgesic activity.},
  author={David L Musso and Felicia R. Cochran and James L Kelley and Ed W McLean and Jeffrey L Selph and Greg C. Rigdon and G Faye Orr and Ronda G Davis and Barrett R. Cooper and Virgil L Styles and James B. Thompson and William R Hall},
  journal={Journal of medicinal chemistry},
  year={2003},
  volume={46 3},
  pages={399-408}
}
The design of rigid cyclic analogues derived from cinnamamide 1, (E)-N-cyclopropyl-3-(3-fluorophenyl)prop-2-enamide, and beta-methylcinnamamide 2, (E)-N-cyclopropyl-3-(3-fluorophenyl)but-2-enamide, has led to the discovery of the potent, centrally acting muscle relaxant (E)-2-(4,6-difluoro-1-indanylidene)acetamide, 17. Compound 17 also possesses potent antiinflammatory and analgesic activity. This paper describes the synthesis and the muscle relaxant, antiinflammatory, and analgesic structure… CONTINUE READING

Similar Papers

Loading similar papers…