Indan analogs of fenfluramine and norfenfluramine have reduced neurotoxic potential.

@article{Cozzi1998IndanAO,
  title={Indan analogs of fenfluramine and norfenfluramine have reduced neurotoxic potential.},
  author={Nicholas V Cozzi and Stewart P Frescas and Danuta Marona-Lewicka and Xiaodong Huang and David E. Nichols},
  journal={Pharmacology, biochemistry, and behavior},
  year={1998},
  volume={59 3},
  pages={709-15}
}
N-Ethyl-5-trifluoromethyl-2-aminoindan (ETAI) and 5-trifluoromethyl-2-aminoindan (TAI) were synthesized to examine the effects of side-chain cyclization on the pharmacology of the anorectic drugs fenfluramine (FEN) and norfenfluramine (norFEN), respectively. ETAI and TAI inhibited synaptosomal accumulation of 5-HT but were less effective at inhibiting… CONTINUE READING