Indacaterol Inhibits Tumor Cell Invasiveness and MMP-9 Expression by Suppressing IKK/NF-κB Activation

@inproceedings{Lee2014IndacaterolIT,
  title={Indacaterol Inhibits Tumor Cell Invasiveness and MMP-9 Expression by Suppressing IKK/NF-κB Activation},
  author={Su Ui Lee and Kyung-Seop Ahn and Min Hee Sung and Ji-Won Park and Hyung Won Ryu and Hyun-Jun Lee and Sung-Tae Hong and Sei-Ryang Oh},
  booktitle={Molecules and cells},
  year={2014}
}
The β2 adrenergic receptor (ADRB2) is a G protein-coupled transmembrane receptor expressed in the human respiratory tract and widely recognized as a pharmacological target for treatments of asthma and chronic obstructive pulmonary disorder (COPD). Although a number of ADRB2 agonists have been developed for use in asthma therapy, indacaterol is the only ultra-long-acting inhaled β2-agonist (LABA) approved by the FDA for relieving the symptoms in COPD patients. The precise molecular mechanism… CONTINUE READING

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