Incubation of cue-induced reinstatement of cocaine, but not sucrose, seeking in C57BL/6J mice.

@article{Nugent2017IncubationOC,
  title={Incubation of cue-induced reinstatement of cocaine, but not sucrose, seeking in C57BL/6J mice.},
  author={Alexandria L. Nugent and Ethan M Anderson and Erin Beth Larson and David W Self},
  journal={Pharmacology, biochemistry, and behavior},
  year={2017},
  volume={159},
  pages={
          12-17
        }
}
Prior studies have shown that drug-seeking behaviors increase, rather than dissipate, over weeks to months after withdrawal from drug self-administration. This phenomenon - termed incubation - suggests that drug-craving responses elicited by conditioned environmental or discrete cues may intensify over pronged abstinence. While most of this work is conducted in rats with intravenous drug self-administration models, there is less evidence for incubation in mice that have greater utility for… CONTINUE READING