Incretins: a new treatment option for type 2 diabetes?

  title={Incretins: a new treatment option for type 2 diabetes?},
  author={Petronella H. L. M. Geelhoed-Duijvestijn},
  journal={The Netherlands journal of medicine},
  volume={65 2},
This article describes how the discovery of a protein almost 100 years ago led to a clinical treatment for type 2 diabetes. Food intake, but also stimulation of the sympathetic nervous system (for example physical exercise), stimulates the secretion of glucagon-like-peptide-1 (GLP-1), derived from the glucagon precursor proglucagon in the small intestine. GLP-1 stimulates the production and secretion of insulin, the release of somatostatin, glucose utilisation by increasing insulin sensitivity… CONTINUE READING
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