Incretin receptors for glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide are essential for the sustained metabolic actions of vildagliptin in mice.

@article{Flock2007IncretinRF,
  title={Incretin receptors for glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide are essential for the sustained metabolic actions of vildagliptin in mice.},
  author={Grace B. Flock and Laurie L. Baggio and Christine Longuet and Daniel J Drucker},
  journal={Diabetes},
  year={2007},
  volume={56 12},
  pages={3006-13}
}
OBJECTIVE Dipeptidyl peptidase-4 (DPP4) inhibitors lower blood glucose in diabetic subjects; however, the mechanism of action through which these agents improve glucose homeostasis remains incompletely understood. Although glucagon-like peptide (GLP)-1 and glucose-dependent insulinotropic polypeptide (GIP) represent important targets for DPP4 activity… CONTINUE READING