Incremental dosage of the new antipsychotic mazapertine induces tolerance to cardiovascular and cognitive effects in healthy men

@article{Kleinbloesem1996IncrementalDO,
  title={Incremental dosage of the new antipsychotic mazapertine induces tolerance to cardiovascular and cognitive effects in healthy men},
  author={Cornelis H. Kleinbloesem and F Jaquet-M{\"u}ller and Yousif Al-Hamdan and Cornelia Baldauf and L G Gisclon and Keith A Wesnes and Christopher R. Curtin and R. John Stubbs and Sally A. Walker and Françoise Brunner‐Ferber},
  journal={Clinical Pharmacology \& Therapeutics},
  year={1996},
  volume={59}
}
Biotransformation of Post-Clozapine Antipsychotics
TLDR
Although the promising benzisoxazole (iloperidone) and benzisothiazole (perospirone) antipsychotics share some metabolic routes with the structurally related available drugs, they too have pharmacologically relevant compound-specific pathways.
Biomarkers for the effects of antipsychotic drugs in healthy volunteers.
TLDR
Subjective and objective measures of alertness, and of visual-visuomotor-auditory and motor skills were most sensitive to antipsychotics, although over half of all the studies failed to show statistically significant differences from placebo.
The acute effects of amisulpride (50 mg and 200 mg) and haloperidol (2 mg) on cognitive function in healthy elderly volunteers
TLDR
The general absence of cognitive impairments with amisulpride at the doses used in this study suggests that this compound does not impair cognitive function in the elderly.
Reboxetine versus paroxetine versus placebo: effects on cognitive functioning in depressed patients
TLDR
Objective data is provided to support the possibility that reboxetine favourably affects cognitive processes in depressed patients and to investigate the effects of other agents used to treat MDD.
The value of assessing cognitive function in drug development
  • K. Wesnes
  • Psychology
    Dialogues in clinical neuroscience
  • 2000
TLDR
Evidence is presented from phase 1 to 3 of the nature and quality of the information that can be obtained by applying the Cognitive Drug Research computerized assessment system to ongoing clinical trials.
An automated system for assessing cognitive function in any environment
  • K. Wesnes
  • Biology, Psychology
    SPIE Defense + Commercial Sensing
  • 2005
The Cognitive Drug Research (CDR) computerized assessment system has been in use in worldwide clinical trials for over 20 years. It is a computer based system which assesses core aspects of human

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