Incremental dosage of the new antipsychotic mazapertine induces tolerance to cardiovascular and cognitive effects in healthy men

  title={Incremental dosage of the new antipsychotic mazapertine induces tolerance to cardiovascular and cognitive effects in healthy men},
  author={Cornelis H. Kleinbloesem and F Jaquet-M{\"u}ller and Yousif Al-Hamdan and Cornelia Baldauf and L G Gisclon and Keith A Wesnes and Christopher R. Curtin and R. John Stubbs and Sally A. Walker and Françoise Brunner‐Ferber},
  journal={Clinical Pharmacology \& Therapeutics},
Biotransformation of Post-Clozapine Antipsychotics
Although the promising benzisoxazole (iloperidone) and benzisothiazole (perospirone) antipsychotics share some metabolic routes with the structurally related available drugs, they too have pharmacologically relevant compound-specific pathways.
Biomarkers for the effects of antipsychotic drugs in healthy volunteers.
Subjective and objective measures of alertness, and of visual-visuomotor-auditory and motor skills were most sensitive to antipsychotics, although over half of all the studies failed to show statistically significant differences from placebo.
The acute effects of amisulpride (50 mg and 200 mg) and haloperidol (2 mg) on cognitive function in healthy elderly volunteers
The general absence of cognitive impairments with amisulpride at the doses used in this study suggests that this compound does not impair cognitive function in the elderly.
Reboxetine versus paroxetine versus placebo: effects on cognitive functioning in depressed patients
Objective data is provided to support the possibility that reboxetine favourably affects cognitive processes in depressed patients and to investigate the effects of other agents used to treat MDD.
The value of assessing cognitive function in drug development
  • K. Wesnes
  • Psychology
    Dialogues in clinical neuroscience
  • 2000
Evidence is presented from phase 1 to 3 of the nature and quality of the information that can be obtained by applying the Cognitive Drug Research computerized assessment system to ongoing clinical trials.
An automated system for assessing cognitive function in any environment
  • K. Wesnes
  • Biology, Psychology
    SPIE Defense + Commercial Sensing
  • 2005
The Cognitive Drug Research (CDR) computerized assessment system has been in use in worldwide clinical trials for over 20 years. It is a computer based system which assesses core aspects of human


Antipsychotic drug doses and neuroleptic/dopamine receptors
It is reported here that all clinically effective antipsychotic drugs (tested so far) block the stereo-specific binding of 3H-haloperidol at concentrations which correlate directly with the clinical potencies.
Atypical neuroleptics: role of multiple receptors, endogenous dopamine, and receptor linkage
  • P. Seeman
  • Psychology
    Acta psychiatrica Scandinavica. Supplementum
  • 1990
The atypical nature of the benzamides may be based on their sensitivity to the level of endogenous dopamine released in the different regions of the brain, which may possibly stem from direct linkage between different receptors coupled through components of the G protein system.
Developments in the drug treatment of schizophrenia.
  • G. Reynolds
  • Psychology, Medicine
    Trends in pharmacological sciences
  • 1992
Psychopharmacology: An introduction
The effects of psychopharmacology on psychiatry and psychology are studied.
A modification of an earlier rating scale for extrapyramidal system disturbance is described, and evidence for the validity and reliability of the scale is presented. The usefulness of the scale in
Possible mechanisms by which repeated clozapine administration differentially affects the activity of two subpopulations of midbrain dopamine neurons
  • L. Chiodo, B. Bunney
  • Biology, Psychology
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1985
Data suggest that anticholinergic and/or alpha 1-NE-blocking properties of clozapine may, in part, mediate its differential effects on A9 and A10 midbrain DA neurons.
A Rating Scale for Drug-Induced Akathisia
  • T. Barnes
  • Psychology
    British Journal of Psychiatry
  • 1989
A rating scale for drug-induced akathisia has been derived that incorporates diagnostic criteria for pseudoakathisia, and mild, moderate, and severe akathisia. It comprises items for rating the