Increment of hypothalamic 2-arachidonoylglycerol induces the preference for a high-fat diet via activation of cannabinoid 1 receptors

@article{Higuchi2011IncrementOH,
  title={Increment of hypothalamic 2-arachidonoylglycerol induces the preference for a high-fat diet via activation of cannabinoid 1 receptors},
  author={Sei Higuchi and Makiko Ohji and Maiko Araki and Riyo Furuta and M. Fujiwara},
  journal={Behavioural Brain Research},
  year={2011},
  volume={216},
  pages={477-480}
}
  • Sei Higuchi, Makiko Ohji, +2 authors M. Fujiwara
  • Published 2011
  • Chemistry, Medicine
  • Behavioural Brain Research
  • The aim of the present study is to examine the relationship between preference for HFD and 2-arachidonoylglycerol (2-AG), endogenous cannabinoid. The 3-day HFD intake induced preference for HFD, which was suppressed by CB1 antagonist, O-2050. Moreover, hypothalamic 2-AG was increased after 3-day HFD intake. Our results show that preference for HFD is induced by activation of CB1 receptors via an increment of 2-AG in hypothalamus. 
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