Increasing throughput and information content for in vitro drug metabolism experiments using ultra-performance liquid chromatography coupled to a quadrupole time-of-flight mass spectrometer.

@article{CastroPrez2005IncreasingTA,
  title={Increasing throughput and information content for in vitro drug metabolism experiments using ultra-performance liquid chromatography coupled to a quadrupole time-of-flight mass spectrometer.},
  author={Jos{\'e} Manuel Castro-P{\'e}rez and Robert Plumb and Jennifer H. Granger and Iain G Beattie and Karine Joncour and Andrew Wright},
  journal={Rapid communications in mass spectrometry : RCM},
  year={2005},
  volume={19 6},
  pages={843-8}
}
The field of drug metabolism has been revolutionized by liquid chromatography/mass spectrometry (LC/MS) applications with new technologies such as triple quadrupoles, ion traps and time-of-flight (ToF) instrumentation. Over the years, these developments have often relied on the improvements to the mass spectrometer hardware and software, which has allowed users to benefit from lower levels of detection and ease-of-use. One area in which the development pace has been slower is in high… CONTINUE READING
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