Increasing the power of association studies with affected families, unrelated cases and controls

@inproceedings{Stewart2013IncreasingTP,
  title={Increasing the power of association studies with affected families, unrelated cases and controls},
  author={William C. L. Stewart and Jane E. Cerise},
  booktitle={Front. Genet.},
  year={2013}
}
When studying the genetics of inherited diseases, researchers often collect data on affected families, unrelated cases, and healthy controls. However, the joint analysis of such heterogeneous data is difficult, and the simpler analysis of homogeneous subsets is often suboptimal. For example, while case-control tests of association are sensitive to allele frequency differences, the preferential transmission of risk alleles from heterozygous parents to their affected offspring is typically… CONTINUE READING