Increasing the exchange time-scale that can be probed by CPMG relaxation dispersion NMR.

Carr-Purcell-Meiboom-Gill relaxation dispersion NMR spectroscopy has emerged as a valuable tool to characterize conformational exchange between major and minor states in a large variety of biomolecules. The window of exchange that is amenable for study, corresponding to rates on the order of 2000 s(-1) or less, is limiting, however. Here we show that a… CONTINUE READING