Increasing the efficacy of bioorthogonal click reactions for bioconjugation: a comparative study.

@article{BesanceneyWebler2011IncreasingTE,
  title={Increasing the efficacy of bioorthogonal click reactions for bioconjugation: a comparative study.},
  author={Christen Besanceney-Webler and Hao Jiang and Tianqing Zheng and Lei Feng and David Soriano del Amo and Wei Wang and Liana M. Klivansky and Florence L Marlow and Yi Liu and Peng Wu},
  journal={Angewandte Chemie},
  year={2011},
  volume={50 35},
  pages={8051-6}
}
Raising the bar: the efficacy of bioorthogonal reactions for bioconjugation has been thoroughly evaluated in four different biological settings. Powered by the development of new biocompatible ligands, the copper-catalyzed azide-alkyne cycloaddition has brought about unsurpassed bioconjugation efficiency, and thus it holds great promise as a highly potent and adaptive tool for a broader spectrum of biological applications.