Increasing the cell number of host tetraploid embryos can improve the production of mice derived from embryonic stem cells.

@article{Ohta2008IncreasingTC,
  title={Increasing the cell number of host tetraploid embryos can improve the production of mice derived from embryonic stem cells.},
  author={Hiroshi Ohta and Yuko Sakaide and Kazuo Yamagata and Teruhiko Wakayama},
  journal={Biology of reproduction},
  year={2008},
  volume={79 3},
  pages={486-92}
}
Tetraploid (4n) embryo complementation assay has shown that embryonic stem (ES) cells alone are capable of supporting embryonic development (ES mouse), allowing the recovery of mouse lines directly from cultured ES cell lines. Although the advantages of this technique are well recognized, it remains inefficient for generating ES mice. In the present study, we investigated the effects of cell number of host 4n embryos on the production of ES mice. Four independent ES cell lines (two general ES… CONTINUE READING
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