Increasing the antitumor effect of an EpCAM-targeting fusion toxin by facile click PEGylation.

@article{Simn2014IncreasingTA,
  title={Increasing the antitumor effect of an EpCAM-targeting fusion toxin by facile click PEGylation.},
  author={Manuel Sim{\'o}n and Nikolas Stefan and Lubor Borsig and Andreas Pl{\"u}ckthun and Uwe Zangemeister-Wittke},
  journal={Molecular cancer therapeutics},
  year={2014},
  volume={13 2},
  pages={375-85}
}
Fusion toxins used for cancer-related therapy have demonstrated short circulation half-lives, which impairs tumor localization and, hence, efficacy. Here, we demonstrate that the pharmacokinetics of a fusion toxin composed of a designed ankyrin repeat protein (DARPin) and domain I-truncated Pseudomonas Exotoxin A (PE40/ETA″) can be significantly improved by facile bioorthogonal conjugation with a polyethylene glycol (PEG) polymer at a unique position. Fusion of the anti-EpCAM DARPin Ec1 to ETA… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-9 of 9 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 57 references

Pl€ uckthunA.Selection and characterization of Her2-binding designed ankyrin repeat proteins

  • ZahndC, F Pecorari, StraumannN, E Wyler
  • J Biol Chem
  • 2006
Highly Influential
6 Excerpts

Therapeutic potential of amanitin-conjugated anti-epithelial cell Simon et al. Mol Cancer Ther

  • G Moldenhauer, AV Salnikov, S L€ uttgau, I Herr, J Anderl, H. Faulstich
  • Molecular Cancer Therapeutics 384 on January
  • 2014
1 Excerpt

Therapeutic potential of amanitin - conjugated anti - epithelial cell adhesion molecule monoclonal antibody against pancreatic carcinoma

  • G Moldenhauer, AV Salnikov, I Herr, J Anderl, H Faulstich
  • J Natl Cancer Inst
  • 2012

Similar Papers

Loading similar papers…