Increasing the CpG dinucleotide abundance in the HIV-1 genomic RNA inhibits viral replication

@inproceedings{AntzinAnduetza2017IncreasingTC,
  title={Increasing the CpG dinucleotide abundance in the HIV-1 genomic RNA inhibits viral replication},
  author={Irati Antzin-Anduetza and Charlotte Mahiet and Luke A. Granger and Charlotte Odendall and Chad M Swanson},
  booktitle={Retrovirology},
  year={2017}
}
BackgroundThe human immunodeficiency virus type 1 (HIV-1) structural protein Gag is necessary and sufficient to form viral particles. In addition to encoding the amino acid sequence for Gag, the underlying RNA sequence could encode cis-acting elements or nucleotide biases that are necessary for viral replication. Furthermore, RNA sequences that inhibit viral replication could be suppressed in gag. However, the functional relevance of RNA elements and nucleotide biases that promote or repress… CONTINUE READING
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