Increasing strut porosity in silicate-substituted calcium-phosphate bone graft substitutes enhances osteogenesis.

@article{Campion2011IncreasingSP,
  title={Increasing strut porosity in silicate-substituted calcium-phosphate bone graft substitutes enhances osteogenesis.},
  author={Charlie R Campion and Chaman Chander and Tom Buckland and Karin Angela Hing},
  journal={Journal of biomedical materials research. Part B, Applied biomaterials},
  year={2011},
  volume={97 2},
  pages={245-54}
}
Synthetic, porous silicate-substituted calcium phosphate bone graft matrices (SiCaP; 0.8 wt % Si) with varying strut porosity were applied to ovine critical-sized defect sites as either 1-2 mm microgranules (SiCaP-23G, SiCaP-32G, and SiCaP-46G) or 1-2 mm microgranules in an aqueous poloxamer carrier (SiCaP-23P, SiCaP-32P, and SiCaP-46P). Defect sites treated with SiCaP-23G or SiCaP-23P showed evidence of bone formation at 8 and 12 weeks in central zones. More advanced neovascularization and… CONTINUE READING
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