Increasing speed and throughput when using HPLC-MS/MS systems for drug metabolism and pharmacokinetic screening.

@article{Hsieh2006IncreasingSA,
  title={Increasing speed and throughput when using HPLC-MS/MS systems for drug metabolism and pharmacokinetic screening.},
  author={Yunsheng Hsieh and Walter A. Korfmacher},
  journal={Current drug metabolism},
  year={2006},
  volume={7 5},
  pages={
          479-89
        }
}
Both combinatorial chemistry and parallel synthesis provide a valuable means for the production of large numbers of compounds with diverse molecular architectures that become available for various drug discovery experiments. In both the lead optimization and lead selection stages, one requirement that is common for many processes is the need for bioanalytical support. This review summarizes current high throughput strategies and efficient methodologies that are employed for drug metabolism and… 

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