Increasing requests for vitamin D measurement: costly, confusing, and without credibility

  title={Increasing requests for vitamin D measurement: costly, confusing, and without credibility},
  author={Naveed Sattar and Paul Welsh and Maurizio Panarelli and Nita G. Forouhi},
  journal={The Lancet},
Trends in the incidence of testing for vitamin D deficiency in primary care in the UK: a retrospective analysis of The Health Improvement Network (THIN), 2005–2015
Testing for vitamin D deficiency increased over the past decade among adults in the UK, and one-third of UK adults who had a vitamin D test performed in primary care were vitamin D deficient, and deficiency was much higher among ethnic minority patients.
Vitamin D: increasing supplement use among at-risk groups (NICE guideline PH56)
  • C. Wood, T. Cheetham
  • Medicine
    Archives of Disease in Childhood: Education & Practice Edition
  • 2015
The Scientific Advisory Committee on Nutrition (SACN) is currently reviewing guidelines for recommended daily intakes of vitamin D and it is advised that people should follow the NICE guidelines in conjunction with future advice published by SACN.
Prevalence of Vitamin D deficiency among pregnant women and effect of Vitamin D supplementation on maternal and fetal outcomes: A double-blind randomized placebo controlled trial
VDD is highly prevalent among pregnant women and is associated with significantly longer duration of labor, particularly among women living in urban areas and having lower sun exposure time.
Vitamin D and calcium intakes in general pediatric populations: A French expert consensus paper.
A Non-Invasive Hair Test to Determine Vitamin D3 Levels
The potential of the vitamin D hair test in clinical assays as a complementary test to a vitamin D blood test, which would provide a quarterly average level of vitamin D, is revealed.
Development and Validation of a Predictive Model of Hypovitaminosis D in General Adult Population: SCOPYD Study
A set of predictors of severe VitD deficiency that are easy to collect in routine that may help to better target patients for serum 25(OH)D concentration determination are identified.
Effectiveness of professional and patient-oriented strategies in reducing vitamin D and B12 test ordering in primary care: a cluster randomised intervention study
A structured intervention programme, including training and benchmarking of GPs regarding their diagnostic test ordering, resulted in a significant reduction in ordered vitamin tests with a structured timelimited programme.
Metabolic and endocrine diseases - is our approach always rational?
These recommendations within Choosing wisely initiative of different professional associations usualy arise from expert views, supported by relevant clinical studies, represent a challange to think over rational management of care.
Reducing vitamin test ordering in primary care; the effectiveness of professional and patient oriented strategies in a Cluster randomized Intervention Study.
A structured intervention programme, including training and benchmarking of GPs regarding their diagnostic test ordering resulted in a significant reduction in ordered vitamin tests.
Risk of hypercalcemia in patients with very high serum 25‐OH vitamin D levels
The objective was to evaluate the risk of hypercalcemia in patients with very high levels of 25‐hydroxy vitamin D (25(OH)D)D and to investigate the mechanisms leading to this condition.


Mutations in CYP24A1 and idiopathic infantile hypercalcemia.
The presence of CYP24A1 mutations explains the increased sensitivity to vitamin D in patients with idiopathic infantile hypercalcemia and is a genetic risk factor for the development of symptomatic hyperCalcemia that may be triggered by vitamin D prophylaxis in otherwise apparently healthy infants.
Vitamin D and prevention of cardiovascular disease and diabetes: why the evidence falls short.
This commentary providesritical appraisal of the relevant evidence, explains why the research was found to be insufficient by the IOM, and identifies future research needs on this topic.
Association of vitamin D status with serum androgen levels in men
This work aimed to investigate the association of 25‐hydroxyvitamin D levels with testosterone, free androgen index (FAI) and SHBG, and examined whether androgen levels show a similar seasonal variation to 25(OH)D.
Diagnosis and management of vitamin D deficiency
The diagnosis and management of vitamin D insufficiency and deficiency in children and adults according to evidence from descriptive and observational studies, randomised trials, and metaanalyses are discussed.
Patient level pooled analysis of 68 500 patients from seven major vitamin D fracture trials in US and Europe
This individual patient data analysis indicates that vitamin D given alone in doses of 10-20 μg is not effective in preventing fractures, and by contrast, calcium and vitamin Dgiven together reduce hip fractures and total fracture, and probably vertebral fractures, irrespective of age, sex, or previous fractures.
Vitamin D Deficiency and Risk of Cardiovascular Disease
Vitamin D deficiency is associated with incident cardiovascular disease and further clinical and experimental studies may be warranted to determine whether correction of vitamin D deficiency could contribute to the prevention of cardiovascular disease.
Hypovitaminosis D in British adults at age 45 y: nationwide cohort study of dietary and lifestyle predictors.
Prevalence of hypovitaminosis D in the general population was alarmingly high during the winter and spring, which warrants action at a population level rather than at a risk group level.
Tetracycline Poisoning in Renal Failure
Another plea is made that drugs of the tetracycline group other than doxycycline should not be given to patients with chronic renal failure.