Increasing radiation dose intensity using hyperfractionation in patients with malignant glioma

@article{Fulton2004IncreasingRD,
  title={Increasing radiation dose intensity using hyperfractionation in patients with malignant glioma},
  author={Dorcas S. Fulton and Raul C. Urtasun and I. Scott-Brown and Edward S. Johnson and Bruce W. Mielke and Burnadette Curry and Debbie Huyser-Wierenga and Jane Hanson and Michael L. Feldstein},
  journal={Journal of Neuro-Oncology},
  year={2004},
  volume={14},
  pages={63-72}
}
We attempted to show a dose effect relationship for radiation therapy by treating patients harbouring malignant glioma with increasing doses of radiation in a step-wise fashion. We postulated that no increase in delayed toxicity would be seen because we used hyperfractionation technique. Between January 1981 and December 1988 we treated 280 patients three times daily at 4 hour intervals. 100 patients received a total dose of 6141 cGy, 73 patients received 7120 cGy, and 107 patients received… 
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