Increasing power of genome-wide association studies by collecting additional single-nucleotide polymorphisms.

Abstract

Genome-wide association studies (GWASs) have been effectively identifying the genomic regions associated with a disease trait. In a typical GWAS, an informative subset of the single-nucleotide polymorphisms (SNPs), called tag SNPs, is genotyped in case/control individuals. Once the tag SNP statistics are computed, the genomic regions that are in linkage… (More)
DOI: 10.1534/genetics.111.128595

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