Increasing plasma [K+] by intravenous potassium infusion reduces NCC phosphorylation and drives kaliuresis and natriuresis.

@article{Rengarajan2014IncreasingP,
  title={Increasing plasma [K+] by intravenous potassium infusion reduces NCC phosphorylation and drives kaliuresis and natriuresis.},
  author={Srinivas Rengarajan and Donna H Lee and Young-Taek Oh and Eric Delpire and Jang Hyun Youn and Alicia A McDonough},
  journal={American journal of physiology. Renal physiology},
  year={2014},
  volume={306 9},
  pages={F1059-68}
}
Dietary potassium loading results in rapid kaliuresis, natriuresis, and diuresis associated with reduced phosphorylation (p) of the distal tubule Na(+)-Cl(-) cotransporter (NCC). Decreased NCC-p inhibits NCC-mediated Na(+) reabsorption and shifts Na(+) downstream for reabsorption by epithelial Na(+) channels (ENaC), which can drive K(+) secretion. Whether the signal is initiated by ingesting potassium or a rise in plasma K(+) concentration ([K(+)]) is not understood. We tested the hypothesis… CONTINUE READING
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