Increasing parvovirus filter throughput of monoclonal antibodies using ion exchange membrane adsorptive pre-filtration.

@article{Brown2010IncreasingPF,
  title={Increasing parvovirus filter throughput of monoclonal antibodies using ion exchange membrane adsorptive pre-filtration.},
  author={Arick Brown and Charity Bechtel and Jerome Bill and Hui Liu and Jun Liu and Dan McDonald and Satyan Pai and Asha Radhamohan and Ryan S. Renslow and Brooke Thayer and Stefan T Yohe and Chris F Dowd},
  journal={Biotechnology and bioengineering},
  year={2010},
  volume={106 4},
  pages={627-37}
}
Pre-filtration using ion exchange membrane adsorbers can improve parvovirus filter throughput of monoclonal antibodies (mAbs). The membranes work by binding trace foulants, and although some antibody product also binds, yields > or =99% are easily achieved by overloading. Results show that foulant adsorption is dependent on pH and conductivity, but… CONTINUE READING