Increasing oxidative stress with molsidomine increases blood pressure in genetically hypertensive rats but not normotensive controls.

Abstract

Spontaneously hypertensive rats (SHR) have a higher level of oxidative stress and exhibit a greater depressor response to a superoxide scavenger, tempol, than normotensive Wistar-Kyoto rats (WKY). This study determined whether an increase in oxidative stress with a superoxide/NO donor, molsidomine, would amplify the blood pressure in SHR. Male SHR and WKY… (More)

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@article{Fortepiani2005IncreasingOS, title={Increasing oxidative stress with molsidomine increases blood pressure in genetically hypertensive rats but not normotensive controls.}, author={Lourdes A. Fortepiani and Jane F. Reckelhoff}, journal={American journal of physiology. Regulatory, integrative and comparative physiology}, year={2005}, volume={289 3}, pages={R763-70} }