Increasing ornithine decarboxylase activity is another way of prolactin preventing methotrexate-induced apoptosis: Crosstalk between ODC and BCL-2

@article{Hsu2006IncreasingOD,
  title={Increasing ornithine decarboxylase activity is another way of prolactin preventing methotrexate-induced apoptosis: Crosstalk between ODC and BCL-2},
  author={P.-C. Hsu and T.-C. Hour and Y.-F. Liao and Y.-C. Hung and C.-C. Liu and W.-H. Chang and M.-C. Kao and Gregory Jiazer Tsay and H.-C. Hung and G.-y. Liu},
  journal={Apoptosis},
  year={2006},
  volume={11},
  pages={389-399}
}
Prolactin has more than 300 separate functions including affecting mammary growth, differentiation, secretion and anti-apoptosis. In the previous studies, prolactin induced Bcl-2 expression to prevent apoptosis and also provoked the activity of ornithine decarboxylase (ODC). Our previous data showed that ODC overexpression upregulates Bcl-2 and prevents tumor necrosis factor alpha (TNF-α)- and methotrexate (MTX)-induced apoptosis. Here, we further investigate whether prolactin prevents MTX… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 12 CITATIONS

Predictive biomarkers in rheumatoid arthritis

VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

References

Publications referenced by this paper.
SHOWING 1-10 OF 60 REFERENCES

by decreasing intracellular reactive oxygen species

CC Huang, PC Hsu, YC Hung
  • 2005

by reducing intracellular reactive oxygen species production

RA Pattillo, GO Gey, E Delfs
  • 2005