Increasing nitric oxide production improves survival in experimental hemorrhagic shock.

@article{Daughters1996IncreasingNO,
  title={Increasing nitric oxide production improves survival in experimental hemorrhagic shock.},
  author={Kenneth Daughters and Kenneth Waxman and Hang Nguyen},
  journal={Resuscitation},
  year={1996},
  volume={31 2},
  pages={
          141-4
        }
}
UNLABELLED The purpose of this study was to evaluate the importance of nitric oxide (NO) upon outcome following hemorrhagic shock. L-Arginine, an NO precursor, and L-NMMA, an inhibitor of NO synthesis, were added to resuscitation in a prospective, randomized, and double-blinded experimental model, and the effects upon blood pressure and survival were measured. METHODS 60 Sprague-Dawley rats were anesthetized and subjected to phlebotomy to induce hemmorrhagic shock. After a 45 min shock period… CONTINUE READING

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