Increasing neutrophil F-actin corrects CD11b exposure in Type 2 diabetes.

Abstract

BACKGROUND Leukocyte dysfunction contributes to the pathogenesis of diabetic vascular complications. Neutrophils adhere to the endothelium through the beta(2)integrin CD11b/CD18. In Type 2 diabetes, neutrophil surface CD11b expression is increased and is associated with impaired actin polymerization. This study aimed to determine whether increasing… (More)

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