Increasing maternal body mass index is associated with systemic inflammation in the mother and the activation of distinct placental inflammatory pathways.

@article{Aye2014IncreasingMB,
  title={Increasing maternal body mass index is associated with systemic inflammation in the mother and the activation of distinct placental inflammatory pathways.},
  author={Irving L. M. H. Aye and Susanne Lager and Vanessa I. Ramirez and Francesca Gaccioli and Donald J. Dudley and T. Jansson and Theresa L. Powell},
  journal={Biology of reproduction},
  year={2014},
  volume={90 6},
  pages={129}
}
Obese pregnant women have increased levels of proinflammatory cytokines in maternal circulation and placental tissues. However, the pathways contributing to placental inflammation in obesity are largely unknown. We tested the hypothesis that maternal body mass index (BMI) was associated with elevated proinflammatory cytokines in maternal and fetal circulations and increased activation of placental inflammatory pathways. A total of 60 women of varying pre-/early pregnancy BMI, undergoing… CONTINUE READING