Increasing intracellular free calcium induces circumferential contractions in isolated cochlear outer hair cells.

@article{Dulon1990IncreasingIF,
  title={Increasing intracellular free calcium induces circumferential contractions in isolated cochlear outer hair cells.},
  author={Didier Dulon and Gary Zajic and Jochen Schacht},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1990},
  volume={10 4},
  pages={1388-97}
}
The relationship between intracellular free calcium and the motile responses of outer hair cells isolated from the guinea pig cochlea was examined. Calcium levels were modulated by the addition of the calcium ionophores ionomycin or A23187 to the incubation medium and monitored with the fluorescent calcium indicator fluo-3. In the presence of 1.25 mM external calcium, the application of either ionophore (10 microM) led to an increase in intracellular free calcium from 157 +/- 76 nM to 1200… CONTINUE READING

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