Increasing incidence of adenovirus disease in bone marrow transplant recipients.


Adenovirus infections in 201 bone marrow transplant (BMT) recipients over 4 years were retrospectively reviewed. Forty-two patients (20.9%) had positive adenovirus cultures after BMT. There was a higher incidence of adenovirus infections in pediatric patients than in adults (31.3% vs. 13.6%, P = .003). In addition, the time of onset of adenovirus infection after transplant was earlier in pediatric patients (mean, < 30 days) than in adults (> 90 days). Adenovirus type 35 was the most common serotype identified. One-third of adenovirus-positive patients had definite or probable adenovirus disease. Moderate to severe acute graft-versus-host disease and isolation of adenovirus from two or more sites were significant risk factors for adenovirus disease. This report documents a higher incidence of both adenovirus infection and disease than do previous studies. Adenovirus may emerge as a more frequent pathogen as more high-risk BMT transplants are done.

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@article{Flomenberg1994IncreasingIO, title={Increasing incidence of adenovirus disease in bone marrow transplant recipients.}, author={Phyllis R Flomenberg and Jonathan Babbitt and William R. Drobyski and Robert C. Ash and Donald R . Carrigan and Gerald V Sedmak and Timothy McAuliffe and Bruce M. Camitta and Mary Horowitz and Nancy J. Bunin}, journal={The Journal of infectious diseases}, year={1994}, volume={169 4}, pages={775-81} }