Increasing extraocular muscle strength with insulin-like growth factor II.

  title={Increasing extraocular muscle strength with insulin-like growth factor II.},
  author={Linda K McLoon and Stephen P. Christiansen},
  journal={Investigative ophthalmology & visual science},
  volume={44 9},
PURPOSE Botulinum toxin type A and, more recently, the immunotoxin ricin-mAb35 have been effective as means of pharmacologically weakening the extraocular muscle. However, currently there are no drug treatments to strengthen an underacting extraocular muscle. In limb muscle, treatment with insulin-like growth factor causes myofiber hypertrophy. In this study, the short-term effects of insulin-like growth factor II (IGF-II) on extraocular muscle morphometry and force generation were examined… CONTINUE READING


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