Increasing endogenous 2‐arachidonoylglycerol levels counteracts colitis and related systemic inflammation

@article{Alhouayek2011IncreasingE2,
  title={Increasing endogenous 2‐arachidonoylglycerol levels counteracts colitis and related systemic inflammation},
  author={Mireille Alhouayek and Didier M. Lambert and Nathalie M. Delzenne and Patrice D Cani and Giulio G. Muccioli},
  journal={The FASEB Journal},
  year={2011},
  volume={25},
  pages={2711 - 2721}
}
Inflammatory bowel diseases (IBDs) are chronic inflammatory conditions for which new therapeutic approaches are needed. Genetic and pharmacological data point to a protective role of CB1 and CB2 cannabinoid receptor activation in IBD experimental models. Therefore, increasing the endogenous levels of 2‐arachidonoylglycerol, the main full agonist of these receptors, should have beneficial effects on colitis. 2‐Arachidonoylglycerol levels were raised in the trinitrobenzene sulfonic acid (TNBS… 
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177 Citations

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Therapeutic potential of monoacylglycerol lipase inhibitors.

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Modulation of the ECS was efficient in ameliorating colitis and increasing the survival rate of the mice, and reducing remote organ changes induced by colitis, suggesting that modulation ofThe ECS is a potential therapeutic approach for IBDs and the associated remote organ lesions.

The endocannabinoid system in inflammatory bowel diseases: from pathophysiology to therapeutic opportunity.

...

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