Increasing effect of sodium 3-ethyl-7-isopropyl-1-azulenesulfonate 1/3 hydrate (KT1-32), a novel antiulcer agent, on gastric mucosal blood flow in anesthetized.

@article{Yano1990IncreasingEO,
  title={Increasing effect of sodium 3-ethyl-7-isopropyl-1-azulenesulfonate 1/3 hydrate (KT1-32), a novel antiulcer agent, on gastric mucosal blood flow in anesthetized.},
  author={Shingo Yano and Shuichi Horie and Shuichi Wakabayashi and Seiichiro Mochizuki and Akira Tomiyama and Kazuo Watanabe},
  journal={Research communications in chemical pathology and pharmacology},
  year={1990},
  volume={70 2},
  pages={
          253-6
        }
}
Effect of a novel azulene derivative KT1-32 on gastric mucosal blood flow (GMBF) was studied to elucidate its mucosal defensive mechanisms underlying the antiulcer action. The GMBF was measured by two methods which were based on heat clearance and laser Doppler velocimetry in the rat. Intravenous administration of KT1-32 produced a dose-dependent increase in GMBF at doses of 0.3-10 mg/kg; significant increases in GMBF were observed at doses not less than 1 or 3 mg/kg by the laser Doppler or… CONTINUE READING

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