Increasing drug solubility by means of bile salt-phosphatidylcholine-based mixed micelles.

@article{Hammad1998IncreasingDS,
  title={Increasing drug solubility by means of bile salt-phosphatidylcholine-based mixed micelles.},
  author={Mohammed A. Hammad and Bernd W. M{\"u}ller},
  journal={European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V},
  year={1998},
  volume={46 3},
  pages={361-7}
}
Study of the solubilization of commercial grades of soya phosphatidylcholine (SPC) with different purities by bile salts (BS) indicated that only highly pure grades of SPC are suitable for the preparation of clear solutions of BS/SPC-mixed micelles (BS/SPC-MM). The solubilizing capacity of different BS towards SPC increased in the following order; Sodium cholate (SC) < sodium deoxycholate (SDC) < sodium glycocholate (SGC). Moreover, egg phosphatidylcholine (EPC) was solubilized to a higher… CONTINUE READING

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