Increasing doses of 5-fluorouracil and high-dose folinic acid in the treatment of metastatic colorectal cancer.

AIMS AND BACKGROUND Combined 5-fluorouracil (5FU) and folinic acid (FA) is the first-line treatment of metastatic colorectal cancer. The aims of this study were to individualize the dose of 5FU in a weekly schedule in which the maximum tolerated dose of 5FU is administered to each patient, and to evaluate the impact of increasing 5FU doses on response and… (More)