Increasing dopamine D2 receptor expression in the adult nucleus accumbens enhances motivation

Abstract

A decrease in dopamine D2 receptor (D2R) binding in the striatum is one of the most common findings in disorders that involve a dysregulation of motivation, including obesity, addiction and attention deficit hyperactivity disorder. As disruption of D2R signaling in the ventral striatum—including the nucleus accumbens (NAc)—impairs motivation, we sought to… (More)
DOI: 10.1038/mp.2013.57

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