Increasing delta-9-tetrahydrocannabinol (Δ-9-THC) content in herbal cannabis over time: systematic review and meta-analysis.

@article{Cascini2012IncreasingD,
  title={Increasing delta-9-tetrahydrocannabinol ($\Delta$-9-THC) content in herbal cannabis over time: systematic review and meta-analysis.},
  author={Fidelia Cascini and Carola Aiello and Gian Luca Di Tanna},
  journal={Current drug abuse reviews},
  year={2012},
  volume={5 1},
  pages={
          32-40
        }
}
AIM The objective of this meta-analysis is to assess the data regarding changes in herbal cannabis potency over time (from 1970 to 2009). METHODS Systematic searches of 17 electronic scientific databases identified studies on this topic, within which 21 case series studies satisfied our inclusion criteria of reporting the mean tetrahydrocannabinol (THC) value per number of samples per year. No language, publication date, publication type or status restrictions were imposed. The study… Expand
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References

SHOWING 1-10 OF 34 REFERENCES
Potency Trends of Δ9‐THC and Other Cannabinoids in Confiscated Cannabis Preparations from 1993 to 2008 *
TLDR
The data showed an upward trend in the mean Δ9‐tetrahydrocannabinol (Δ9‐THC) content of all confiscated cannabis preparations, which increased from 3.4% in 1993 to 8.8% in 2008, mainly due to the increase in the potency of nondomestic versus domestic samples. Expand
Potency of Δ9–THC and Other Cannabinoids in Cannabis in England in 2005: Implications for Psychoactivity and Pharmacology *
TLDR
The increases in average THC content and relative popularity of sinsemilla cannabis, combined with the absence of the anti‐psychotic cannabinoid CBD, suggest that the current trends in cannabis use pose an increasing risk to those users susceptible to the harmful psychological effects associated with high doses of THC. Expand
Variation in the THC content in illicitly imported Cannabis products.
TLDR
The tetrahydrocannabinol (THC) content of 304 seizures of illicit Cannabis products was determined using gas chromatography, which results in the conversion of THC acid to THC itself and thus gives the total THC content, which reflects its potency as experienced by the smokers. Expand
A note on the cannabinoid content of Jamaican ganja.
TLDR
The analytical results agreed well with those of Rubin and Comitas, and indicated that samples with a delta9-THC content of 4.0% or more were apt to be comparatively rare, and local judgement as to the potency of samples proved generally sound, although by no means infallible. Expand
A note on the cannabinoid content of Jamaican ganja.
TLDR
The analytical results agreed well with those of Rubin and Comitas, and indicated that samples with a delta9-THC content of 4.0% or more were apt to be comparatively rare, and local judgement as to the potency of samples proved generally sound, although by no means infallible. Expand
Variations of tetrahydrocannabinol content in cannabis plants to distinguish the fibre-type from drug-type plants.
TLDR
A study of the characteristics of cannabis seeds and the influence of environmental conditions on the content of THC in cannabis plants grown in northern, southern and insular Italy has shown that the fibre-type plants contain mean values of THCranging in a range from 0.058 to 0.299 per cent. Expand
Cannabinoid contents in cannabis products seized in São Paulo, Brazil, 2006–2007
A rapid and simple method was optimized for determination of Δ9-tetrahydrocannabinol (Δ9-THC), cannabidiol (CBD), and cannabinol (CBN) contents in cannabis products by gas chromatography withExpand
Delat9-tetrahydrocannabinol content in cannabis plants of greek origin.
TLDR
The delta9-tetrahydrocannabinol (delta9-THC) content was identified and determined quantitatively using a Gas Chromatography Detector (Gas Chromatography-Electron Ion Detector) instrument in samples of illicit herbal cannabis, suggesting that Greece might be at high risk, as an area for the illicit cultivation of "pedigree" cannabis plants. Expand
Strong increase in total delta‐THC in cannabis preparations sold in Dutch coffee shops
TLDR
Whether the increase in THC levels causes increased health risks for users can only be concluded when more data are available on adjusted patterns of use, abuse liability, bioavailability and levels of THC in the brain. Expand
Determination of cannabinoids in cannabis products using liquid chromatography-ion trap mass spectrometry.
TLDR
A method was developed and validated for the simultaneous determination of five cannabinoids in cannabis products and unequivocal confirmation according to the most stringent EU criteria was possible. Expand
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