Increasing anticonvulsant effect of AD-810 (zonisamide) in aging BDF1 mice.

  title={Increasing anticonvulsant effect of AD-810 (zonisamide) in aging BDF1 mice.},
  author={Kenichi Kitani and Yuzo Sato and Setsuko Kanai and Munetaka Nokubo and Minoru Ohta and Yoshinobu Masuda},
  journal={Life sciences},
  volume={41 11},
The anticonvulsant efficacy of a newly developed anticonvulsant, AD-810 (zonisamide, 3-sulfamoylmethyl-1,2-benzisoxazole) was examined in relation to mouse age in three different age groups of female BDF1 mice (7-, 25- and 29-month-old). The minimal effective concentration (MEC) of AD-810 in both plasma and brain for abolishing the electroshock-induced maximal seizure steadily decreased with age, the 25- and 29-month values being 50 and 30% of respective 7-month values. The observation in the… CONTINUE READING