Increasing annual incidence of vestibular schwannoma and age at diagnosis

  title={Increasing annual incidence of vestibular schwannoma and age at diagnosis},
  author={Sven Eric Stangerup and Mirko Tos and Per Cay{\'e}-Thomasen and Tina Tos and Mads Klokker and Jens Christian Thomsen},
  journal={The Journal of Laryngology \& Otology},
  pages={622 - 627}
During the last 26 years the annual number of diagnosed vestibular schwannomas (VS) has been increasing. The aim of this study is to describe and analyse this increase. Since 1976, 1446 new cases of VS have been diagnosed at the authors’ centre. Special focus was on the age at diagnosis, the localization and the size of the tumour. The size of the tumour was registered as either intrameatal or with the largest extrameatal diameter. The annual number of diagnosed VS has increased from 26 in 1976… 
Epidemiology Of Vestibular Schwannomas – Prospective 40-Year Data From An Unselected National Cohort
Over the past 40 years, the incidence rate of vestibular schwannomas has increased steadily from 3 VS/million/year to 34 VS/ million/year, primarily due to easier access to improved diagnostics and the finding of more tumors in older people.
True Incidence of Vestibular Schwannoma?
After a steady increase over the last 4 decades, the incidence of vestibular schwannomas appears to have peaked and decreased in recent years, stabilizing at about 19 tumors per million per year.
The Natural History of Vestibular Schwannoma
Growth of vestibular schwannomas occurs within the first 5 years after diagnosis in a limited number of tumors, primarily in tumors with an extrameatal extension, and there is no relation between tumor growth and sex or age.
Socio-demographic distribution of vestibular schwannomas in Denmark
V Vestibular schwannomas (VSs) are diagnosed less frequently in the remote parts of Denmark, whereas the diagnostic age and tumor size is the same across the different socio-demographic areas of Denmark.
Vestibular schwannomas – when should conservative management be reconsidered?
There remains a place for conservative treatment in those with small tumours, the elderly and those with significant co-morbidities, and only growth in the first year of follow-up was found to significantly predict total growth.
Spontaneous tumour shrinkage in 1261 observed patients with sporadic vestibular schwannoma
Findings substantiate the ‘wait and scan’ strategy for tumours with a largest extrameatal diameter of up to 20 mm and confirm the rate of spontaneous tumour shrinkage in patients with sporadic vestibular schwannoma is four per cent.
Determinants of Vestibular Schwannoma Growth.
  • Mantegh Sethi, D. Borsetto, P. Axon
  • Medicine
    Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • 2020
Determinants of VS growth are described, allowing clinicians to move toward a more personalized approach to growth-risk profiling, and were found to be extracanalicular VS and small-sized VS more likely to grow than IC VS, but only in the first year after diagnosis.
Expectant management of vestibular schwannoma: a retrospective multivariate analysis of tumor growth and outcome.
No growth within 5 years of surveillance does not guarantee a continued indolent growth pattern; surveillance must therefore continue.


Incidence of vestibular schwannomas
The observed increase in the diagnosis of the small and intrameatal tumor creates a clinical dilemma, whether to operate on tumors in this early stage or to allocate patients to the wait‐and‐scan group.
What is the real incidence of vestibular schwannoma?
The incidence of vestibular schwannoma in Denmark is compared with that of previous periods, and a realistic mean incidence depends on the observation period, which suggests a realistic incidence of approximately 13 VS/1 million inhabitants per year.
Acoustic neuromas. Diagnostic delay, growth rate and possible non-surgical treatment.
It is demonstrated that both patients and physicians are to some extent still ignoring the possible significance of a unilateral, progressive, sensorineural hearing impairment, and a more differentiated attitude towards indications for surgery is needed.
Clinical experience with vestibular schwannomas: epidemiology, symptomatology, diagnosis, and surgical results
The present paper reflects the experience the Danish model for vestibular schwannoma surgery has gained in two decades of VS surgery, with studies on the incidence, symptomatology, diagnosis, expectancy and surgical results.
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The incidence of primary intracranial tumors in Manitoba, Canada was reviewed and the clinical features and pathologic patterns of these tumors were not unlike those previously reported in the literature.
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Incidence of acoustic neuromas.
The annual incidence of diagnosed acoustic neuromas in Denmark during two 7-year periods from June 1976 to June 1990 was compared, collecting all operated and non-operated tumors from the entire
Management of vestibular schwannomas (acoustic neuromas): auditory and facial nerve function after resection of 120 vestibular schwannomas in patients with neurofibromatosis 2.
For patients with NF-2, the presentation ages are lower, tumor progression is faster, the chances of anatomic and functional nerve preservation are higher, and good outcomes are best when surgery is performed early and when there is good preoperative hearing function, and the danger of sudden hearing loss is higher.
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The age-specific incidence pattern for tumors of the brain and cranial meninges in Connecticut over a 30-year period shows an early peak followed by a taller and sharper peak with a maximum in the
Epidemiology, pathogenesis, and genetics of acoustic tumors.