Increasing annual incidence of vestibular schwannoma and age at diagnosis

@article{Stangerup2004IncreasingAI,
  title={Increasing annual incidence of vestibular schwannoma and age at diagnosis},
  author={Sven Eric Stangerup and Mirko Tos and Per Cay{\'e}-Thomasen and Tina Tos and Mads Klokker and Jens Christian Thomsen},
  journal={The Journal of Laryngology \& Otology},
  year={2004},
  volume={118},
  pages={622 - 627}
}
During the last 26 years the annual number of diagnosed vestibular schwannomas (VS) has been increasing. The aim of this study is to describe and analyse this increase. Since 1976, 1446 new cases of VS have been diagnosed at the authors’ centre. Special focus was on the age at diagnosis, the localization and the size of the tumour. The size of the tumour was registered as either intrameatal or with the largest extrameatal diameter. The annual number of diagnosed VS has increased from 26 in 1976… 
Epidemiology Of Vestibular Schwannomas – Prospective 40-Year Data From An Unselected National Cohort
TLDR
Over the past 40 years, the incidence rate of vestibular schwannomas has increased steadily from 3 VS/million/year to 34 VS/ million/year, primarily due to easier access to improved diagnostics and the finding of more tumors in older people.
True Incidence of Vestibular Schwannoma?
TLDR
After a steady increase over the last 4 decades, the incidence of vestibular schwannomas appears to have peaked and decreased in recent years, stabilizing at about 19 tumors per million per year.
The Natural History of Vestibular Schwannoma
TLDR
Growth of vestibular schwannomas occurs within the first 5 years after diagnosis in a limited number of tumors, primarily in tumors with an extrameatal extension, and there is no relation between tumor growth and sex or age.
Socio-demographic distribution of vestibular schwannomas in Denmark
TLDR
V Vestibular schwannomas (VSs) are diagnosed less frequently in the remote parts of Denmark, whereas the diagnostic age and tumor size is the same across the different socio-demographic areas of Denmark.
Vestibular schwannomas – when should conservative management be reconsidered?
TLDR
There remains a place for conservative treatment in those with small tumours, the elderly and those with significant co-morbidities, and only growth in the first year of follow-up was found to significantly predict total growth.
Spontaneous tumour shrinkage in 1261 observed patients with sporadic vestibular schwannoma
TLDR
Findings substantiate the ‘wait and scan’ strategy for tumours with a largest extrameatal diameter of up to 20 mm and confirm the rate of spontaneous tumour shrinkage in patients with sporadic vestibular schwannoma is four per cent.
Determinants of Vestibular Schwannoma Growth.
  • Mantegh Sethi, D. Borsetto, P. Axon
  • Medicine
    Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • 2020
TLDR
Determinants of VS growth are described, allowing clinicians to move toward a more personalized approach to growth-risk profiling, and were found to be extracanalicular VS and small-sized VS more likely to grow than IC VS, but only in the first year after diagnosis.
Expectant management of vestibular schwannoma: a retrospective multivariate analysis of tumor growth and outcome.
TLDR
No growth within 5 years of surveillance does not guarantee a continued indolent growth pattern; surveillance must therefore continue.
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