Increasing Wnt signaling in the bone marrow microenvironment inhibits the development of myeloma bone disease and reduces tumor burden in bone in vivo.

@article{Edwards2008IncreasingWS,
  title={Increasing Wnt signaling in the bone marrow microenvironment inhibits the development of myeloma bone disease and reduces tumor burden in bone in vivo.},
  author={Claire M Edwards and James M Edwards and Seint T. Lwin and Javier Esparza and Babatunde O. Oyajobi and Brandon W. McCluskey and Steven Munoz and Barry Grubbs and Gregory R. Mundy},
  journal={Blood},
  year={2008},
  volume={111 5},
  pages={2833-42}
}
There is increasing evidence to suggest that the Wnt signaling pathway plays a critical role in the pathogenesis of myeloma bone disease. In the present study, we determined whether increasing Wnt signaling within the bone marrow microenvironment in myeloma counteracts development of osteolytic bone disease. C57BL/KaLwRij mice were inoculated intravenously with murine 5TGM1 myeloma cells, resulting in tumor growth in bone and development of myeloma bone disease. Lithium chloride (LiCl… CONTINUE READING