Increasing Versus Maintaining the Dose of Olanzapine or Risperidone in Schizophrenia Patients Who Did Not Respond to a Modest Dosage: A Double-Blind Randomized Controlled Trial.

@article{Sakurai2016IncreasingVM,
  title={Increasing Versus Maintaining the Dose of Olanzapine or Risperidone in Schizophrenia Patients Who Did Not Respond to a Modest Dosage: A Double-Blind Randomized Controlled Trial.},
  author={Hitoshi Sakurai and Takefumi Suzuki and Robert R Bies and Bruce G. Pollock and Masaru Mimura and Shitij Kapur and Hiroyuki Uchida},
  journal={The Journal of clinical psychiatry},
  year={2016},
  volume={77 10},
  pages={1381-1390}
}
OBJECTIVE While doctors often increase the dose of an antipsychotic when there is insufficient response, there is limited evidence that this intervention is any better than waiting longer on the lower dose. We put the proposition to test. METHOD In this 4-week, double-blind, randomized controlled trial conducted in psychiatric care from September 2012 to March 2015, 103 patients with schizophrenia (ICD-10) who did not respond to olanzapine 10 mg/d or risperidone 3 mg/d were randomly allocated… CONTINUE READING