Increasing Kaposi's sarcoma‐associated herpesvirus seroprevalence with age in a highly Kaposi's sarcoma endemic region, Zambia in 1985

  title={Increasing Kaposi's sarcoma‐associated herpesvirus seroprevalence with age in a highly Kaposi's sarcoma endemic region, Zambia in 1985},
  author={Sonja J Olsen and Yuan Chang and Patrick S. Moore and Robert J. Biggar and Mads Melbye},
Background:Kaposi's sarcoma (KS)-associated herpesvirus (KSHV) is a newly discovered virus found in all forms of KS. In the United States, KSHV infection appears to be most common amongst individuals at high-risk for KS. Preliminary data from Africa suggest that KSHV infection may be much more common in the general population. Objective:To examine the KSHV seroprevalence and age-specific patterns of infection in an African country with high rates of KS. Design:Cross-sectional seroprevalence… 
The epidemiology of Kaposi’s sarcoma associated-herpesvirus in Uganda
An investigation of factors that might impact on transmission of Kaposi’s sarcoma associated-herpesvirus (KSHV) and the first prospective study of antibody titre to KSHV to determine risk of KS from Africa are described and reported.
Review of the distribution of Kaposi's sarcoma-associated herpesvirus (KSHV) in Africa in relation to the incidence of Kaposi's sarcoma
The evidence reviewed here shows that the causal virus–Kaposi's sarcoma associated herpesvirus (KSHV)–is prevalent in many African countries, including places where Kaposi's Sarcoma was almost unknown before HIV, and that it is as common in women as in men.
Kaposi’s Sarcoma-Associated Herpesvirus: Epidemiology, Biological Characteristics and Pathogenesis
Globally useful or population-based prognostic and predictive biomarkers for KSHV-related disorders still need to be defined to guide physicians in the choice of therapeutic strategies and to selectively monitor patients at risk.
A systematic approach was used to standardize the assessment of KSHV infection rates and examined seroprevalence rates among high-risk populations of clinical interest and identified two multi-antigen algorithms: one that maximized sensitivity and one that Maximized specificity.
Humoral and cellular immune responses against Kaposi's sarcoma-associated herpesvirus (KSHV).
Seroepidemiological studies were conducted in African, Middle Eastern, Mediterranean European and South American countries to determine the infection rate, and to determine risk factors and possible routes of KSHV transmission, and a new quantitative real-time PCR method was developed to detect K SHV in clinical samples.
Seroepidemiology and molecular epidemiology of Kaposi's sarcoma-associated herpesvirus among Jewish population groups in Israel.
The presence of K SHV in Jews in Israel of all ethnic origins and their high incidence of reported Kaposi's sarcoma suggest that KSHV was introduced into the Jewish population prior to the major Diaspora.
Prevalence of Kaposi's sarcoma‐associated herpesvirus infection in haemophilic patients
The seroprevalence of KSHV in patients with haemophilia was investigated by serological methods (anti-KSHV antibodies) and detection of K SHV DNA in blood by using the BCP-1 cell line.
Prevalence of human herpesvirus 8 infection before the acquired immunodeficiency disease syndrome-related epidemic of Kaposi's sarcoma in East Africa.
Assessment of the KSHV/HHV8 seroprevalence in the rural populations of the West Nile District in Uganda and the North Mara District in Tanzania during the period prior to the onset of the AIDSrelated epidemic of KS indicates that, during the 1970s, inhabitants of rural areas of Uganda and Tanzania exhibited an overall KSHv/ HHV8Serop revalence similar to that observed in recent years.
Epidemiology and pathogenesis of Kaposi's sarcoma-associated herpesvirus.
  • C. Boshoff, R. Weiss
  • Medicine
    Philosophical transactions of the Royal Society of London. Series B, Biological sciences
  • 2001
The histogenesis, clonality and pathology of the tumours are described, together with the epidemiology and possible modes of transmission of the virus.


Risk factors for Kaposi's‐sarcoma‐associated herpesvirus (KSHV/HHV‐8) seropositivity in a cohort of homosexual men, 1981–1996
KSHV/HHV‐8 appears to be sexually transmitted, probably by receptive anal intercourse, and may have been introduced to Danish homosexual men via sex with US men and by the same activities that lead to the spread of HIV.
Seroconversion to antibodies against Kaposi's sarcoma-associated herpesvirus-related latent nuclear antigens before the development of Kaposi's sarcoma.
In most patients with kaposi's sarcoma and AIDS, seroconversion to positivity for antibodies against KSHV-related nuclear antigens occurs before the clinical appearance of Kaposi's Sarcoma.
The seroepidemiology of human herpesvirus 8 (Kaposi's sarcoma–associated herpesvirus): Distribution of infection in KS risk groups and evidence for sexual transmission
The data support the inference that this virus is the etiologic cofactor predicted by the epidemiology of KS, and the distribution of HHV8 seropositivity conforms to that expected for a sexually transmitted pathogen and tracks closely with the risk for KS development.
KSHV antibodies among Americans, Italians and Ugandans with and without Kaposi's sarcoma
Antibody kinetics showed that more than half of the AIDS–KS patients who were examined IgG–seroconverted before KS development, and antibody levels did not decline after seroconversion, suggest that the rate of infection was constant and that the risk of developing KS once infected with KSHV is not highly dependent on the duration of infection.
Frequent detection of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) DNA in saliva of human immunodeficiency virus-infected men: clinical and immunologic correlates.
The data suggest that KSHV can replicate in the oropharynx and that salivary contact could contribute to KSHVs transmission and that virions from saliva to DNase treatment was consistent with the presence of virions.
Infection with AIDS-related herpesviruses in human immunodeficiency virus-negative infants and endemic childhood Kaposi's sarcoma in Africa.
In Zambia, an AIDS epidemic and KS endemic region, infection with these novel herpesviruses during infancy is examined, providing the first demonstration that HHV-6 variant A andHHV-8 may be acquired as common childhood infections.
Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma.
unique sequences present in more than 90 percent of Kaposi's sarcoma tissues obtained from patients with acquired immunodeficiency syndrome (AIDS) appear to define a new human herpesvirus.