Increasing Internodal Distance in Myelinated Nerves Accelerates Nerve Conduction to a Flat Maximum

@inproceedings{Wu2012IncreasingID,
  title={Increasing Internodal Distance in Myelinated Nerves Accelerates Nerve Conduction to a Flat Maximum},
  author={Lai Man N. Wu and Anna C Williams and Ada Delaney and Diane L Sherman and Peter J Brophy},
  booktitle={Current Biology},
  year={2012}
}
Predictions that conduction velocities are sensitive to the distance between nodes of Ranvier in myelinated axons have implications for nervous system function during growth and repair. Internodal lengths defined by Schwann cells in hindlimb nerves, for example, can undergo a 4-fold increase during mouse development, and regenerated nerves have internodes that are uniformly short. Nevertheless, the influence of internodal length on conduction speed has limited experimental support. Here, we… CONTINUE READING