Increasing Fatty Acid Oxidation Remodels the Hypothalamic Neurometabolome to Mitigate Stress and Inflammation

@inproceedings{McFadden2014IncreasingFA,
  title={Increasing Fatty Acid Oxidation Remodels the Hypothalamic Neurometabolome to Mitigate Stress and Inflammation},
  author={Joseph W. McFadden and Susan M. Aja and Qun Li and Veera Venkata Ratnam Bandaru and Eun-kyoung Kim and Norman J Haughey and Francis P. Kuhajda and Gabriele V. Ronnett},
  booktitle={PloS one},
  year={2014}
}
Modification of hypothalamic fatty acid (FA) metabolism can improve energy homeostasis and prevent hyperphagia and excessive weight gain in diet-induced obesity (DIO) from a diet high in saturated fatty acids. We have shown previously that C75, a stimulator of carnitine palmitoyl transferase-1 (CPT-1) and fatty acid oxidation (FAOx), exerts at least some of its hypophagic effects via neuronal mechanisms in the hypothalamus. In the present work, we characterized the effects of C75 and another… CONTINUE READING
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