Increases in severity of lung damage and mortality by treatment with cyclo and lipoxygenase inhibitors in bleomycin and hyperoxia model of lung injury in hamsters.

@article{Giri1987IncreasesIS,
  title={Increases in severity of lung damage and mortality by treatment with cyclo and lipoxygenase inhibitors in bleomycin and hyperoxia model of lung injury in hamsters.},
  author={Shri N. Giri and Dallas M. Hyde},
  journal={Pathology},
  year={1987},
  volume={19 2},
  pages={150-8}
}
Effects of ibuprofen (I), a cyclooxygenase inhibitor, and of nordihydroguaiaretic acid (NDGA), a lipoxygenase inhibitor, on bleomycin (B) and hyperoxia (H) induced acute lung damage and mortality were studied in hamsters. Hamsters, after receiving bleomycin, 0.25 unit, intratracheally were treated subcutaneously with vehicle (BHV group), ibuprofen, 10 mg/kg, (BHI group) or NDGA 10 mg/kg (BHNDGA group) and then exposed to 70% oxygen (O2) for 72 h. Daily treatment in each case continued for 14… CONTINUE READING