Increases in cerebral cortical perfusate adenosine and inosine concentrations during hypoxia and ischemia.

@article{Phillis1987IncreasesIC,
  title={Increases in cerebral cortical perfusate adenosine and inosine concentrations during hypoxia and ischemia.},
  author={John W. Phillis and Gesa Walter and Michael H. O'Regan and Richard Stair},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={1987},
  volume={7 6},
  pages={679-86}
}
The cerebral cortical cup technique was used to monitor changes in adenosine and inosine levels in the rat cerebral cortex during periods of hypoxia, anoxia, or hemorrhagic hypotension. Basal levels of adenosine and inosine in cortical perfusates stabilized within 10 min at concentrations of 30-50 and 75-130 nM, respectively. Comparable levels were observed in normal CSF collected from the cisterna magna. Reductions in the oxygen content of the inspired air (14, 12, 8, and 5% oxygen) resulted… CONTINUE READING

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