Increases in alpha4* but not alpha3*/alpha6* nicotinic receptor sites and function in the primate striatum following chronic oral nicotine treatment.

@article{McCallum2006IncreasesIA,
  title={Increases in alpha4* but not alpha3*/alpha6* nicotinic receptor sites and function in the primate striatum following chronic oral nicotine treatment.},
  author={Sarah E. McCallum and Neeraja Parameswaran and Tanuja Bordia and Hong Fan and Rachel F. Tyndale and James William Langston and John McIntosh and Maryka Quik},
  journal={Journal of neurochemistry},
  year={2006},
  volume={96 4},
  pages={1028-41}
}
Knowledge of the effects of chronic nicotine is critical considering its widespread use in tobacco products and smoking cessation therapies. Although nicotine is well known to up-regulate alpha4* nAChR sites and function in the cortex, its actions in the striatum are uncertain because of the presence of multiple subtypes with potentially opposing effects. We therefore investigated the effect of long-term nicotine treatment on nAChR sites and function in the primate striatum, which offers the… CONTINUE READING