Increases in Hydrophilicity and Charge on the Polar Face of Alyteserin 1c Helix Change its Selectivity towards Gram-Positive Bacteria

@article{Liscano2019IncreasesIH,
  title={Increases in Hydrophilicity and Charge on the Polar Face of Alyteserin 1c Helix Change its Selectivity towards Gram-Positive Bacteria},
  author={Yamil Liscano and Constain H Salamanca and Lina Vargas and Stefania Cantor and Valentina Laverde-Rojas and Jos{\'e} O{\~n}ate-Garz{\'o}n},
  journal={Antibiotics},
  year={2019},
  volume={8}
}
Recently, resistance of pathogens towards conventional antibiotics has increased, representing a threat to public health globally. As part of the fight against this, studies on alternative antibiotics such as antimicrobial peptides have been performed, and it has been shown that their sequence and structure are closely related to their antimicrobial activity. Against this background, we here evaluated the antibacterial activity of two peptides developed by solid-phase synthesis, Alyteserin 1c… Expand
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